Nanostructured lipid carrier surface modified with eudragit rs 100 and its potential ophthalmic functions wenji zhang,1,3, xuedong li,2, tiantian ye,3 fen chen,3 shihui yu,3 jianting chen,3 xinggang yang,3 na yang,2 jinsong zhang,2 jinlu liu,2 weisan pan,3 jun kong2 1department of pharmaceutics, school of traditional chinese medicine, shenyang pharmaceutical university, shenyang, peoples. Eudragit rs100, a nonbiodegradable polymer with varying ratios was used for. Preparation and physicochemical characterization the objective of the present study was to. Introduction today, arthritis affects millions of people of all age groups. The aim of this study was to prepare eudragit retard l eudragit rl nanoparticles enps and to determine their properties, their uptake by the human thp1 cell line in vitro and their effect on the hematological parameters and erythrocyte damage in rats. Development and in vivoin vitroevaluation of dexketoprofen trometamol dtloaded nano sized, controlled release drug delivery system was aimed in this study dtloaded kollidon sr ksr and eudragit rs 100 ers polymeric nanoparticles were prepared using nano spraydryer b90, buch. The polymers used for coating are ethyl cellulose eudragit rs 100. Separately, different amounts of eudragit rl 100 140, 245, and 350 mg were dissolved. Dexketoprofen trometamolloaded eudragit rl 100 nanoparticle. Two nonbiodegradable polymers, eudragit rs100 and rl100 were used in combination. Preparation of eudragit s100singlecoat celecoxibloaded microparticles eudragit s100 singlecoat celecoxibloaded microparticles formula f9 were prepared using a solvent diffusion technique. Propranolol hydrochloride was microencapsulated with different polymers ethylcellulose, eudragit rs, and. Introduction drug delivery research is clearly moving from the micro to the nano size scale.
The 22 factorial design was employed to evaluate the effect of drug. The nanoparticles were prepared with the different ratios of drug and eudragit rs100 and eudragit s100 polymer using. The size of the particles could be fine tuned by the polymeric composition, the production method and the solvent. Eudragit rs 100 is a polymethacrylate, with a chemical names such as poly ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride, having low amount of. Microspheres were prepared by varying the amount of polyvinyl. Cationic plgaeudragit rl nanoparticles for increasing. The objective of the present study was to formulate desloratadineeudragit rs100 nanoparticles and investigate the. Accaddeemm icc sscieencceess international journal of. Pdf dexketoprofen trometamolloaded kollidon sr and. The encapsulation efficiency was greater than 90% and the drug weight content. It is a solid substance in form of a white powder with a faint characteristic odour. Nanoparticles were prepared by the solvent evaporation method. In one of these studies, spray dried nanoparticles were obtained using eudragit rs 100 and kollidon sr polymers 4. Polymeric nps of amb were prepared with eudragit rl 100 by solvent displacement technique.
The objective of present study was to develop an optimized polymeric nanoparticle system for the antiretroviral drug tenofovir. For this purpose, nanoparticles nps with the mucoadhesive properties of eudragit rs 100 and the penetration enhancing and peptide protective properties of cds. It is mixed in solution with crosslinkers to form the polymer. Muhammad faizan nazar, muhammad yasir siddique, muhammad atif saleem, muddassar zafar, faisal nawaz, muhammad ashfaq, asad muhammad khan, hafiz muhammad abd ur rahman, muhammad bilal tahir, azwan mat lazim. Copolymer, eudragit l 100 are anionic copolymers based on methacrylic acic and methyl methacrylate. Solapur, india, eudragit l100 was purchased from research lab chemical centre, mumbai, india, poly vinyl alcohol, methanol and. Development and in vitro evaluation of flurbiprofen. Sr no name of the drug taste masking approach 01 risperidone ph control and from rwe 44 at albany college of pharmacy and health sciences.
Thus, the positive zeta potential and fine particle size would help in prolonging the corneal contact time. Formulation and characterization of ketorolac tromethamine. Preparation of nanoparticles consisting of methacrylic polymers and. Particles size and zeta potential were measured by malvern zetasizer, surface morphology was done by tem, drug interaction was. Nov, 20 in this study, polymeric microspheres containing diclofenac sodium were prepared by single emulsion oilinwater solvent evaporation method and evaluated for their size, morphology, encapsulation efficiency, drug loading, and in vitro drug release. The nanoparticles were evaluated for particle size, entrapment efficiency, surface morphology, xray diffraction xrd, fourier transform spectroscopy ftir, and differential scanning calorimetry dsc. Diclofenac generates severe adverse effects with risks of toxicity. Different polymer combinations of eudragit rs 100 allow customtailored release profiles to achieve the desired drug delivery performance. Nanoparticles as sustain release drug delivery system using eudragit rs 100 was reported for drugs like acyclovir 2, aceclofenac 3,4,5. Eudragit rs100 is a polymer has been commonly employed for the. The eudragit eud series of polymers have been used for a long time as the coating film for solid dosage forms providing targeted or controlled drug delivery. The smallest particles of 210 nm were found in batch cnsb 200mg eudragit content and the largest particles of 270 nm were seen in batch cnse 400 eudragit content table2. Evonik has been leveraging its highly flexible portfolio for sustained release to help pharmaceutical companies optimize drug effectiveness and improve patient compliance for more than 50 years.
Cationic plga eudragit rl nanoparticles for increasing. In a similar study, the same technique but a different polymer, eudragit rl 100. Briefly, an accurate amount of celecoxib was suspended in water 100 ml. Research article nanoformulated eudragit lopinavir and preliminary release of its loaded suppositories lebogang katataserua, babatunde moses ojoa, omotunde okubanjob, rebeccah soremekunc, oluwole samuel aremua a department of chemistry, faculty of natural and agricultural sciences, northwest university, mmabatho, ma. The decrease in drug release compare to eudragit s formulation esf to eudragit l formulation elf was due to higher concentration of the polymer.
For the encapsulation ability, ketoloaded rs nanoparticle showed 9. The ftir and dsc studies revealed that there is no interaction between drug and excipients used. The use of eudragit rs 100cyclodextrin nanoparticles for. Design of eudragit rl nanoparticles by nanoemulsion method. Preparation and in vitro evaluation of ethylcellulose and. The mixture was emulsified using 55% power of ultrasonic probe sonoplus, hd 2070. Design of eudragit rl 100 nanoparticles by nanoprecipitation. Aug 31, 2016 year of introduction eudragit grade 1954 eudragit l 12.
We obtained nanoparticles characterized by a mean diameter of 57 to 208 nm and a positive surface charge 39 to 74 mv. Eudragit rs 100, chitosan, nanoparticles, emulsion droplet coalescence method, control release. We obtained nanoparticles characterized by a mean diameter of 57 to 208 nm. Eudragit rs100 was selected as best formulation fn8 amongst all formulations. Abstractthe purpose of this study was to develop floating microparticles containing pioglitazone hcl, for controlled release and perform pharmacodynamic studies.
Xray diffraction patterns of nanoparticles containing ketoprofen, eudragit e100 and eudragit rs showed the amorphous structure. Highlights we developed efavirenzloaded pcl, eudragit rs 100 and pcl eudragit rs 100 blend submicron particles. A modified nanoprecipitation method was used to prepare eudragit rs po nanoparticles of the drug. Eudragit rs 100 is a polymethacrylate, with a chemical names such as poly ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride, having low amount of quaternary ammonium attached which gives phindependent permeability and renders the film form by rs 100 less permeable to water 3. Formulation and evaluation of carvedilol loaded eudragit e. Vtt technical research centre of finland, vuorimiehentie 5, p. Nanoformulated eudragit lopinavir and preliminary release. Formulation and characterization of ketorolac tromethamine nanoparticle with eudragit rs100 and rl100 by nano precipitation methodinternational journal of research in pharmacy and biosciences v4 i1 january 2017 19 partition coefficient determination the partition coefficient between noctanolwater was determined at room temperature 30.
Eudragit rl 100 based kf nanoparticles prepared by nanoemulsion method with different drug to polymer ratios showed high entrapment efficiency, low poly dispersity index and positive zeta potential. However, the concept of controlling the burst effect by encapsu. Eudragit rs 100 type b are described in the pharmaceutical european monograph. Preparation, optimization and in vitro evaluation of glipizide nanoparticles integrated with eudragit rs 100 article pdf available march 2019 with 25 reads how we measure reads. The effect of amount of polymer, surfactant concentration, and sonication time on particle size, particle distribution, encapsulation efficiency ee, and zeta potential. Rs 100 eurs100 nanoparticles nps were prepared by using the nanoprecipitation technique. Aug 10, 2010 the aim of this study was to formulate and characterize eudragit l100 and eudragit l100polylacticcoglycolic acid plga nanoparticles containing diclofenac sodium. The present work explored the development of submicron particles made of poly. Development of a nanoprecipitation method for the entrapment. Request pdf naproxeneudragit r rs100 nanoparticles. Nanotechnology is therefore emerging as a field in medicine that is expected to elicit significant therapeutic benefits. Formulation and in vitro evaluation of antineoplastic drug. International journal of research in pharmaceutical and nano sciences.
They are preferred for increasing the absorption of active substance, for increasing bioavailability and for targeting therapeutic agents to specific organs. Design, statistical optimisation, characterisation and. International journal of research in pharmaceutical. Preparation and characterisation of nanoparticles containing. The sponge acts as a threedimensional network or scaffold, which consist of the backbone known as longlength polyester. The data in table2 suggest that an increase in polymer concentration increases the size of the nanoparticles. Pdf comparative study of eudragit rs 100 and rl 100.
Oral evaluation in rabbits of cyclosporinloaded eudragit. The purpose of the recent study was to prepare and estimate sustained release of ethylcellulose 300 cps and eudragit rs 100 and rl 100 microparticles containing propranolol hydrochloride used as a treatment of cardiovascular system, especially hypertension. Fourthgeneration antibiotic gatifloxacin encapsulated by microemulsions. All the reagents and solvents used were of analytical grade satisfying pharmacopeia standards table 1. Formulation and in vitro characterization of eudragit l100.
Preparation and characterization of ketoprofen loaded. Eudragit is employed as a coating material, usually for the coating of pellets or particles that are filled into capsules or compressed into tablets. Aug 10, 2010 preparation of eudragit l100 and eudragitplgadiclofenac sodium nanoparticles. Ltd dehradun, eudragit rs 100, eudragit s100, poloxamer 188 were purchased from central drug house ltd, new delhi. Calibration curve of dl was constructed by plot ting.
The aim of this work was to develop and characterize new nanoparticle systems based on eudragit rs 100 and cyclodextrins cds for the transmucosal administration of glutathione gsh. Present work deals with the preparation and evaluation of fenofibrateloaded nanoparticles by precipitation method. Pharmaceutical nanotechnology provide insights into the synthesis, characterisation and pharmaceutical or diagnostic application of materials at the nanoscale. Eudragit polymer form dissolution properties rl 100 granules insoluble rl po powder high permeability rl 30 d 30 % aqueous dispersion phindependent rl 12,5 12. The microspheres were prepared by single emulsion oilinoil oo solvent evaporation method. Polymeric nanosuspensions were prepared from eudragit rl 100 and eudragit rs 100 observing that they are approved by usfda as an excipient for controlled drug delivery. Two sharp endotherms were obtained with amb at 109. Cationic plga eudragit rl nanoparticles for increasing retention time in synovial cavity after intraarticular injection in knee joint sung rae kim,1 myoung jin ho,2 eugene lee,3 joon woo lee,3 young wook choi,1 myung joo kang21college of pharmacy, chungang university, dongjakgu, seoul, 2college of pharmacy, dankook university, dongnamgu, cheonan, chungnam, 3department of radiology, seoul. Formulation and in vitro characterization of eudragit. Colontargeted celecoxibloaded eudragit s100coated poly. The use of eudragit rs 100 cyclodextrin nanoparticles for the transmucosal administration of glutathione.
These pellets or particles act as diffusion cells in the digestive tract and release a constant drug quantity per unit of time multiunit dosage forms fig 4. Preparation, optimization and in vitro evaluation of glipizide na. Nanostructured lipid carrier surface modified with eudragit. The predicted and actual values of drug release at 1 h, 8 h and drug entrapment were 38.
Preparation, optimization and in vitro evaluation of glipizide. Prepared nano particles were evaluated for particle size, surface morphology, zeta potential, % process yield, % association effi. Drug release was slow from eudragit rs 100 compared to eudragit rl 100 nps and this may be due to the greater aqueous permeability of eudragit rl 100 polymer 34. The word nanotechnology, arise from the greek word nano meaning drawf, technology means application to the engineering, electronics, physical, material science medical. Full text nanostructured lipid carrier surface modified. The nanoparticles of dr with ers were formulated by spray drying method. Development of risedronate sodiumloaded nanosponges by. The result showed that particles were spherical with submicron size. Materials and methods rs was procured from manus aktteva biopharma llp, ahmedabad, india. The ammonium groups are present as salts and make the polymers permeable. Preparation, optimization and in vitro evaluation of.
Preparation, characterization and in vitro evaluation of. Hpmc is a white, colourless, odorless powder which is available in various forms and grades 3. Eudragit e, and eudragit rs, which are commonly used methacrylic polymers in. The particle size was dependent on the rs concentration, emulsification tools and the types of organic solvents. The physical mixture of amb and eudragit rl 100 also showed an endothermic peak of amb at about 218c indicating presence of crystalline state of amb. This solution was added into 8 ml of pva solutions 3% wv containing diclofenac sodium in the amber glass vial. Nanoparticles of natural polymers which are made up of like sodium alginate, chitosan, are very effective in intraocular penetration for some specific drugs, because of. The antibacterial activity of the obtained systems against escherichia coli was in vitro. Optimization of a new nonviral vector for transfection. These nanoparticles were evaluated for surface morphology, particle size.
In the present study, ocular kf loaded eudragit rl 100 nanoparticles were prepared using ow solvent diffusion method. The aim of the present work is to formulate nanoparticles using eudragit rs100 polymer using the solvent evaporation method and optimize and evaluate sustained release nanoparticles to improve its. Nanosponges are tiny sponges with a size of about a virus 250nm 1. These nanoparticles were evaluated for surface morphology. The purpose of the study was to formulate dirithromycin dr loaded eudragit rs 100 ers nanoparticles for topical application and to analyze the physical and chemical characteristics and in vitro toxicity of the prepared formulations. Pdf on nov 29, 2016, alpana ram and others published comparative study of eudragit rs 100 and rl 100 nanoparticles as ophthalmic vehicle for fungal infection find, read and cite all the. An equivalent amount of eudragit s100 was dissolved in ethyl alcohol. Different polymer combinations of eudragit rl and rs grades to allow tailored release eudragit polymer availability dissolution properties rl 100 granules insoluble rl po powder high permeability rl 30 d 30 % aqueous dispersion phindependent swelling rl 12,5 12. Materials and methods fenofibrate was received as a gift sample from smruthi organics pvt. Mucoadhesive nanoparticles as carrier systems for prolonged. Pdf preparation, optimization and in vitro evaluation of. Materials free fulltext uptake of eudragit retard l.
Dtloaded eudragit rl 100 polymeric nanoparticles were prepared using. The resulting particle suspension was separated from unincorporated drug by centrifugation. In vitro drug release study of native nebivolol, nebivolol eudragit rs 100 nanoparticles nnp6 and marketed formulation mean sem, n 3. Nanoparticle suspensions, prepared from eudragit rs 100. For encapsulating diclofenac sodium into eudragit nanoparticles, 100 mg of eudragit l 100 was dissolved in anhydrous ethanol. In vitro, in vivo and pharmacokinetic assessment of. Nanostructured lipid carrier surface modified with. The floating microparticles were prepared by solvent evaporation technique. The thermograms of amb, formulation containing drug, eudragit rl 100, and drugfree np formulations were studied.
Preparation and characterization of atenolol laden. Polymer coating of drugs the polymer coat allows the time for all of the particles to be swallowed before the threshold concentration is reached in the mouth and the taste is perceived. Design of vancomycin rs100 nanoparticles in order to increase the. Formulation and optimization of eudragit rs potenofovir. Thus, nanoparticles were prepared to reduce these drawbacks in the present study. Our broad range of insoluble, ph independent swelling, highly permeable eudragit rl and low permeable eudragit rs polymer grades can be combined with each. In this study, polymeric microspheres containing diclofenac sodium were prepared by single emulsion oilinwater solvent evaporation method and evaluated for their size, morphology, encapsulation efficiency, drug loading, and in vitro drug release.
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